The Noblest of Drugs follows a day in the life of Stan, an outlaw artist trapped in a totalitarian society where the arts are considered as harmful as narcotics. Stan's journey represents an amalgam of plot points and characters from Witkacy's life and plays, including his musings on the mechanization of society, the allure of demonic women, the weakening of the arts’ ability to inebriate and the corollary destruction of a new generation of artists.